Inter Miami`s 1-0 victory keeps them undefeated, while FC Cincinnati and Charlotte FC lead the Eastern Conference.

Inter Miami CF secured a narrow 1-0 victory over Columbus Crew, maintaining their status as the last undefeated team in Major League Soccer (MLS) on April 21, 2025. The match, held in front of 60,614 fans, saw Miami rise to 18 points with five wins, while Columbus also holds 18 points but sits in fourth place in the Eastern Conference.

FC Cincinnati and Charlotte FC both achieved crucial victories, propelling them to the top of the Eastern Conference with 19 points each. Charlotte FC continued their perfect home record with a dominant 3-0 win against San Diego FC, where Liel Abada scored early and Patrick Agyemang netted his first MLS penalty goal. FC Cincinnati edged Chicago 3-2, with Evander scoring twice and Matt Miazga returning from injury.

In the Western Conference, Seattle Sounders FC triumphed over Nashville SC with a 3-0 scoreline, extending their unbeaten home streak to eight matches. Jesús Ferreira shone with two assists, marking his 91 career MLS goal contributions at just 24 years old. Meanwhile, Vancouver Whitecaps, despite being held to a scoreless draw by St. Louis CITY SC, remain at the top of the Western Conference. Sporting Kansas City triumphed in an eight-goal thriller, defeating San Jose Earthquakes 5-3, while LAFC and Portland Timbers played to an exhilarating 3-3 draw.

Upcoming fixtures include Charlotte FC hosting New England Revolution on April 26, 2025.

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